Which statement about URL Protection is TRUE?

The statement about URL Protection that is true is that it can operate without device enrollment. This means that the protection mechanism can be applied to users accessing URLs regardless of whether their devices are formally enrolled in a management system or not. URL Protection functionalities are designed to help safeguard users while they navigate the internet by evaluating links in emails or web pages to identify and block malicious content, enhancing security without tightly coupling to device policies.

This capability allows organizations to maintain a level of security across a wider range of user devices, including those that may not be managed directly by the IT department. The importance of this feature is particularly highlighted in environments where users may utilize personal devices or guest devices that aren't enrolled in the organization's security protocols.

The other statements do not accurately reflect the functionality of URL Protection. For instance, it does not solely depend on specific types of URLs, nor is it ineffective against phishing attempts since it is designed to identify and mitigate such threats.